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<br>This can affect the normal development of reproductive organs and the homeostatic regulation of sex hormone levels. This finding is inconsistent with what we observed in a linear regression model, and [43.139.240.37](http://43.139.240.37:17000/eulaliamcginni) a study using a mixture containing MEP, MEHP, MBP, MiBP, MiNP, and MBzP on gene expression in the sex steroid hormone synthesis and degradation pathway. The BKMR framework can identify nonlinear and nonadditive associations among the chemicals being considered. This model enables the detection of potential interactions and incorporates the exposure‒response patterns of each component within the chemical mixture.
When the concentration of the chemical mixture was greater than 50 quantiles, the FAI and TT/E2 were negatively correlated. Therefore, additional large-scale prospective cohort studies and empirical investigations are imperative to substantiate the current evidence base within the medical field. Additionally, we used raw data from the NHANES database and substituted values below the limit of detection (LOD) with a standardized figure to ensure an unbiased estimation of effects instead of using multiple interpolation.
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